Xanthomonas fuscans subsp. fuscans

5 hits

XFF4834R_chr18650 tldD XFF4834R_chr18650 probable peptidase TldD
XFF4834R_chr18670 tldE XFF4834R_chr18670 probable peptidase TldE (PmbA)
XFF4834R_chr22210 XFF4834R_chr24170719_2568318_f1_XFF4834R-XFF4834R_chr22210 XFF4834R_chr22210 putative O-methyltransferase
XFF4834R_chr26010 XFF4834R_chr_3005234_3005890_f2_XFF4834R-XFF4834R_chr26010 XFF4834R_chr26010 putative HNH nuclease
XFF4834R_chr42450 XFF4834R_chr_4927858_4928139_f1_XFF4834R-XFF4834R_chr42450 XFF4834R_chr42450 putative toxin of the YafQ-DinJ toxin-antitoxin system

tldD XFF4834R_chr18650

XFF4834R_chr_2000

ID	tldD
AC	XFF4834R_chr18650
LT	XFF4834R_chr18650
OR	XFF4834R_chr from 2135361 to 2136806 on strand +
DE	probable peptidase TldD
IP	Peptidase U62, modulator of DNA gyrase
CL	5.10 Defense/survival GO:0006952
EC
GO	InterPro Curated
PM
AN	tldD is annotated predicted peptidase in GenProtEC (Putative modulator of DNA gyrase) 2 physiological roles in GenProtEC Information transfer --> Protein related --> Export, signal peptide cleavage Cell processes --> Defense/survival Microcin B17 (MccB17) is a peptide antibiotic produced by Escherichia coli strains carrying the pMccB17 plasmid. MccB17 is synthesized as a precursor containing an amino-terminal leader peptide that is cleaved during maturation. Maturation requires the product of the chromosomal tldE (pmbA) gene. Mature microcin is exported across the cytoplasmic membrane by a dedicated ABC transporter. In sensitive cells, MccB17 targets the essential topoisomerase II DNA gyrase. Independently, tldE as well as tldD mutants were isolated as being resistant to CcdB, another natural poison of gyrase encoded by the ccd poison-antidote system of plasmid F. This led to the idea that TldD and TldE could regulate gyrase function. We present in vivo evidence supporting the hypothesis that TldD and TldE have proteolytic activity. We show that in bacterial mutants devoid of either TldD or TldE activity, the MccB17 precursor accumulates and is not exported. Similarly, in the ccd system, we found that TldD and TldE are involved in CcdA and CcdA41 antidote degradation rather than being involved in the CcdB resistance mechanism. Interestingly, sequence database comparisons revealed that these two proteins have homologues in eubacteria and archaebacteria, suggesting a broader physiological role.
CC	COG: [R] General function prediction only;
CC	MODEL: XFF4834R
CC	STATUS: curated by darrasse (20120307)
MW	50710.6 Da
SQ	481 aa
	........10........20........30........40........50 \| \| \| \| \| MTDNALTLAETRLLLPSGLDAGHLDRTFGALLGPGIDFGDLYFQHSRRES WSVEDGIVKDGAHSIEQGVGVRAIAGEKTGFAYSDDIHRDALLEAAQSAR AISREGGAQSTRSLVRGNGRALYPATDTIDDMDSATKVDLLRRIDQFLRA ADPRVKQVMVSLSGGVDTVLIARSDGALAADVRPLVRLNVQVIVEQGGRR ESGYSGGGGRYGYADLFADGRPEGFAREALRQALVNLDAIPAPAGVMPVV LGPGWPGVLLHEAVGHGLEGDFNRKGTSVYAGRIGERVASPGVTIVDDGT LDGRRGSLNIDDEGTPSQCTTLIEDGVLVGYMQDSHNARLMGVAPTGNGR RESFAHLTMPRMTNTYMRAGQHDPEEMIRSVKKGIYAVNFGGGQVDITSG KYVFSATEAYLIEDGKVTAPVKGATLIGNGPETMQKVRMIGNDLALDEGV GVCGKDGQSVPVGVGQPSLLIDGITVGGTQA

Domain decomposition

XFF4834R_chr01320 lcl|XFF4834R_chr_0163473_0165101_f3_XFF4834R-XFF4834R_chr01320

236

479

S=192 I=30 E=1.29996e-16

XFF4834R_chr01330 lcl|XFF4834R_chr01440794_0167428_f2_XFF4834R-XFF4834R_chr01330

229

479

S=179 I=28 E=5.66872e-15

XFF4834R_chr18670 lcl|pmbA-XFF4834R_chr18670

444

S=152 I=25 E=1.09691e-11

predicted peptidase required for the maturation and secretion of the antibiotic peptide MccB17

NP_643076.1 lcl|tldD-XAC2767

481

S=2367 I=96 E=0

TldD protein

YP_364654.1 lcl|tldD-XCV2923

481

S=2365 I=96 E=0

putative modulator of DNA gyrase TldD

NP_637954.1 lcl|tldD-XCC2606

481

S=2294 I=92 E=0

TldD protein

lcl|tldD-XALc_2458

479

S=2083 I=83 E=0

putative modulator of dna gyrase protein

NP_635490.1 lcl|tldD-XCC0095

219

479

S=199 I=30 E=7.0313e-17

TldD protein

NP_640478.1 lcl|tldD-XAC0122

244

479

S=188 I=29 E=1.59443e-15

TldD protein

YP_361824.1 lcl|XCV0093

236

479

S=187 I=30 E=2.05312e-15

putative modulator of DNA gyrase

NP_635489.1 lcl|tldD-XCC0094

229

479

S=184 I=28 E=5.79439e-15

TldD protein

YP_361823.1 lcl|XCV0092

229

479

S=178 I=28 E=2.39998e-14

putative modulator of DNA gyrase

NP_640477.1 lcl|tldD-XAC0121

229

479

S=178 I=28 E=2.39998e-14

TldD protein

P0AGG8 sp|P0AGG8|TLDD_ECOLI

479

S=1445 I=59 E=3.20084e-166

Protein tldD

Pubmed 8604133

prodomImg

Q692Z9 sp|Q692Z9|Q692Z9_YEREN

479

S=1430 I=59 E=2.29431e-164

Putative DNA gyrase modulator

Pubmed 16177365

prodomImg

B3U4U3 sp|B3U4U3|B3U4U3_9BACT

481

S=1250 I=54 E=1.39449e-142

Peptidase U62

Pubmed 18459973

prodomImg

Q45224 sp|Q45224|Q45224_BRAJA

481

S=1182 I=54 E=2.68713e-134

TldD

Pubmed 8825087

prodomImg

Q93FP8 sp|Q93FP8|Q93FP8_EHRRU

373

447

S=305 I=79 E=4.89754e-28

Hypothetical tldD protein

Pubmed 11587856

prodomImg

B3U4U4 sp|B3U4U4|B3U4U4_9BACT

446

S=299 I=27 E=2.15617e-27

Peptidase U62

Pubmed 18459973

prodomImg

Q8KNH0 sp|Q8KNH0|Q8KNH0_MICEC

258

480

S=229 I=31 E=6.53815e-19

CalR6

Pubmed 12183629

prodomImg

Q9L6I6 sp|Q9L6I6|Q9L6I6_STRLN

222

480

S=170 I=29 E=9.45663e-12

LmbIH

Pubmed 11816970

prodomImg

P0AFK0 sp|P0AFK0|PMBA_ECOLI

222

454

S=128 I=24 E=1.18133e-06

Protein pmbA ; Cytoplasm

Pubmed 2082149,8604133

prodomImg

Q54362 sp|Q54362|Q54362_STRLN

222

328

S=117 I=38 E=2.43382e-05

LmbI protein

Pubmed 8577249

prodomImg

IPR002510 [PF01523]

331

Peptidase U62, modulator of DNA gyrase

[seg]

197

213

PD002926

476

S=851 I=43 E=1.65495e-95

PD040622

102

190

S=245 I=57 E=3.75618e-22

PDA1F8S5

232

275

S=222 I=93 E=2.57537e-19

PD040623

S=207 I=65 E=1.61968e-17

PDA1V2N8

S=160 I=100 E=7.03939e-12

PDA233U0

386

417

S=146 I=81 E=3.52919e-10

PDA1S981

386

439

S=139 I=54 E=2.445e-09

PDA4Z3O2

348

446

S=137 I=29 E=4.58045e-09

PDA1T9R0

430

454

S=115 I=88 E=1.99573e-06

PD455129

283

385

S=115 I=34 E=2.17754e-06

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ID
DE
EC
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PM
CC
CL
	Your email
	Validation code (copy this one ETrs6hFZ)

Access unfiltered results

	Set of Uniprot with relevant PubMed cross-references ncbi-blastp	10 hits
	Swiss-Prot ncbi-blastp	17 hits
	Xanthomonas fuscans subsp. fuscans proteome ncbi-blastp	3 hits
	HAMAP scan	0 hits
	IprScan	2 hits

Miscellaneous analyses

ERROR Tag PERLLIB Portal/Tools.pl GetLocalBlastButton\("/www/bacteria/annotation//site//www/bacteria/annotation//site/tmp/WB7w4KCm/XFF4834R_chr18650.xml_fasta", "https://iant.toulouse.inra.fr/bacteria/annotation/web/img/XFF4834R.png"\) - ERROR: No such file or directory at /www/bacteria/annotation/cgi/XFF4834R/../../lib/iANT/Entry/Display.pm line 164.

ERROR Tag PERLLIB Portal/Tools.pl GetNcbiBlastButton\("/www/bacteria/annotation//site//www/bacteria/annotation//site/tmp/WB7w4KCm/XFF4834R_chr18650.xml_fasta", "blastp"\) - ERROR: No such file or directory at /www/bacteria/annotation/cgi/XFF4834R/../../lib/iANT/Entry/Display.pm line 164.

ERROR Tag PERLLIB Portal/Tools.pl GetUniprotBlastButton\("/www/bacteria/annotation//site//www/bacteria/annotation//site/tmp/WB7w4KCm/XFF4834R_chr18650.xml_fasta"\) - ERROR: No such file or directory at /www/bacteria/annotation/cgi/XFF4834R/../../lib/iANT/Entry/Display.pm line 164.

ERROR Tag PERLLIB Portal/Tools.pl GetKeggBlastButton\("/www/bacteria/annotation//site//www/bacteria/annotation//site/tmp/WB7w4KCm/XFF4834R_chr18650.xml_fasta", "blastp"\) - ERROR: No such file or directory at /www/bacteria/annotation/cgi/XFF4834R/../../lib/iANT/Entry/Display.pm line 164.

tldE XFF4834R_chr18670

ID	tldE
AC	XFF4834R_chr18670
LT	XFF4834R_chr18670
OR	XFF4834R_chr from 2137789 to 2139156 on strand +
DE	probable peptidase TldE (PmbA)
IP	Peptidase U62, modulator of DNA gyrase
CL	5.10 Defense/survival GO:0006952
EC	3.4.-.-
GO	InterPro Curated
PM
AN	tldE (pmbA) is annotated predicted peptidase required for the maturation and secretion of the antibiotic peptide MccB17 (Putative modulator of DNA gyrase) in GenProtEC 2 Physiological roles in GenProtEC Information transfer --> Protein related --> Export, signal peptide cleavage Cell processes --> Defense/survival Cell processes --> Protection --> Cell killing Location of gene products --> Cytoplasm Microcin B17 (MccB17) is a peptide antibiotic produced by Escherichia coli strains carrying the pMccB17 plasmid. MccB17 is synthesized as a precursor containing an amino-terminal leader peptide that is cleaved during maturation. Maturation requires the product of the chromosomal tldE (pmbA) gene. Mature microcin is exported across the cytoplasmic membrane by a dedicated ABC transporter. In sensitive cells, MccB17 targets the essential topoisomerase II DNA gyrase. Independently, tldE as well as tldD mutants were isolated as being resistant to CcdB, another natural poison of gyrase encoded by the ccd poison-antidote system of plasmid F. This led to the idea that TldD and TldE could regulate gyrase function. We present in vivo evidence supporting the hypothesis that TldD and TldE have proteolytic activity. We show that in bacterial mutants devoid of either TldD or TldE activity, the MccB17 precursor accumulates and is not exported. Similarly, in the ccd system, we found that TldD and TldE are involved in CcdA and CcdA41 antidote degradation rather than being involved in the CcdB resistance mechanism. Interestingly, sequence database comparisons revealed that these two proteins have homologues in eubacteria and archaebacteria, suggesting a broader physiological role.
CC	COG: [R] General function prediction only;
CC	MODEL: XFF4834R
CC	STATUS: curated by darrasse (20120307)
MW	48010.1 Da
SQ	455 aa
	........10........20........30........40........50 \| \| \| \| \| MNALSSEIRVTDDSLQRLDALTDISQRLLERARAAGATQAEVSCSEERGL DVNVRLGDVETVESTRDRGIAVTVYFGKRKGSASTADLQDSSLESTVAQA CAIARFTEDDVAAGLADPELMAREFPELDSWHPWALDADTAVDLALACET AGRDADARISNSDGASASTGLSLSVYANSHGFIGRERGTHHSISCALIAG QGDGMQRDGWYSSALAREDLEAPDAIGRHAAERTVARLQPRSLPTGQLPV LFAPEVARSLVGHLLGAVSGGALYRRASFLLDSVGSKLFPDWFNIEELPH LRRGLRSAAFDGEGVATRRSALITDGVLQRYVLGSYSARKLGLQTTANAG GVHNLQVTANAGDLASMIAGMSRGLLVTELMGNGVNPVTGDYSRGAGGFW IENGVIAYPVDGLTVAGNLRDMFAGIEAVGSDVDPRSHVKIGSVLINRMT VAGDS

Domain decomposition

XFF4834R_chr01340 lcl|XFF4834R_chr_0167443_0168777_f1_XFF4834R-XFF4834R_chr01340

433

S=176 I=24 E=1.34933e-14

XFF4834R_chr18650 lcl|tldD-XFF4834R_chr18650

223

433

S=145 I=27 E=6.75355e-11

predicted peptidase

NP_643074.1 lcl|pmbA-XAC2765

455

S=2264 I=96 E=0

PmbA protein

YP_364651.1 lcl|pmbA-XCV2920

455

S=2264 I=96 E=0

putative modulator of DNA gyrase; peptidase U62 protein PmbA

NP_637952.1 lcl|pmbA-XCC2604

455

S=2175 I=92 E=0

PmbA protein

lcl|pmbA-XALc_2456

453

S=1765 I=76 E=0

putative modulator of dna gyrase protein

NP_640476.1 lcl|tldD-XAC0120

433

S=184 I=25 E=4.70263e-15

TldD protein

NP_635488.1 lcl|tldD-XCC0093

433

S=182 I=24 E=8.65757e-15

TldD protein

YP_361822.1 lcl|XCV0091

433

S=181 I=25 E=1.13443e-14

putative modulator of DNA gyrase

NP_643076.1 lcl|tldD-XAC2767

223

433

S=145 I=27 E=2.77547e-10

TldD protein

YP_364654.1 lcl|tldD-XCV2923

223

433

S=144 I=27 E=2.97597e-10

putative modulator of DNA gyrase TldD

NP_637954.1 lcl|tldD-XCC2606

223

433

S=143 I=26 E=3.93366e-10

TldD protein

P0AFK0 sp|P0AFK0|PMBA_ECOLI

453

S=1012 I=47 E=9.34881e-114

Protein pmbA ; Cytoplasm

Pubmed 2082149,8604133

prodomImg

B3U4U4 sp|B3U4U4|B3U4U4_9BACT

453

S=843 I=41 E=2.48407e-93

Peptidase U62

Pubmed 18459973

prodomImg

Q9RB05 sp|Q9RB05|Q9RB05_ERWCT

166

S=146 I=39 E=8.12749e-09

Putative antibiotic maturation factor

Pubmed 10658663

prodomImg

B3U4U3 sp|B3U4U3|B3U4U3_9BACT

228

433

S=131 I=27 E=5.48073e-07

Peptidase U62

Pubmed 18459973

prodomImg

Q45224 sp|Q45224|Q45224_BRAJA

302

433

S=118 I=30 E=1.71596e-05

TldD

Pubmed 8825087

prodomImg

IPR002510 [PF01523]

331

Peptidase U62, modulator of DNA gyrase

[seg]

135

147

PD002926

452

S=828 I=44 E=8.025e-93

PDA1F9E7

133

S=151 I=55 E=8.32039e-11

PDA1J7N6

231

280

S=136 I=53 E=6.67968e-09

PDA1F9Z8

S=133 I=58 E=1.25137e-08

PD574559

285

410

S=132 I=34 E=1.77355e-08

PDA1T8C5

S=125 I=96 E=1.37617e-07

PDA01060

149

233

S=120 I=36 E=5.00122e-07

PDA1G2T0

191

231

S=120 I=56 E=5.90227e-07

PD820807

148

185

S=109 I=53 E=1.05768e-05

PDA3O973

419

454

S=107 I=56 E=1.91353e-05

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ID
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EC
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Access unfiltered results

	Set of Uniprot with relevant PubMed cross-references ncbi-blastp	5 hits
	Swiss-Prot ncbi-blastp	13 hits
	Xanthomonas fuscans subsp. fuscans proteome ncbi-blastp	2 hits
	HAMAP scan	0 hits
	IprScan	2 hits

Miscellaneous analyses

ERROR Tag PERLLIB Portal/Tools.pl GetLocalBlastButton\("/www/bacteria/annotation//site//www/bacteria/annotation//site/tmp/WB7w4KCm/XFF4834R_chr18670.xml_fasta", "https://iant.toulouse.inra.fr/bacteria/annotation/web/img/XFF4834R.png"\) - ERROR: No such file or directory at /www/bacteria/annotation/cgi/XFF4834R/../../lib/iANT/Entry/Display.pm line 164.

ERROR Tag PERLLIB Portal/Tools.pl GetNcbiBlastButton\("/www/bacteria/annotation//site//www/bacteria/annotation//site/tmp/WB7w4KCm/XFF4834R_chr18670.xml_fasta", "blastp"\) - ERROR: No such file or directory at /www/bacteria/annotation/cgi/XFF4834R/../../lib/iANT/Entry/Display.pm line 164.

ERROR Tag PERLLIB Portal/Tools.pl GetUniprotBlastButton\("/www/bacteria/annotation//site//www/bacteria/annotation//site/tmp/WB7w4KCm/XFF4834R_chr18670.xml_fasta"\) - ERROR: No such file or directory at /www/bacteria/annotation/cgi/XFF4834R/../../lib/iANT/Entry/Display.pm line 164.

ERROR Tag PERLLIB Portal/Tools.pl GetKeggBlastButton\("/www/bacteria/annotation//site//www/bacteria/annotation//site/tmp/WB7w4KCm/XFF4834R_chr18670.xml_fasta", "blastp"\) - ERROR: No such file or directory at /www/bacteria/annotation/cgi/XFF4834R/../../lib/iANT/Entry/Display.pm line 164.

XFF4834R_chr24170719_2568318_f1_XFF4834R-XFF4834R_chr22210 XFF4834R_chr22210

ID	XFF4834R_chr24170719_2568318_f1_XFF4834R-XFF4834R_chr22210
AC	XFF4834R_chr22210
LT	XFF4834R_chr22210
OR	XFF4834R_chr from 2567719 to 2568318 on strand +
DE	putative O-methyltransferase
IP	O-methyltransferase, family 3
CL	5.10 Defense/survival GO:0006952
EC	2.1.1.-
GO	InterPro Molecular Function: O-methyltransferase activity (GO:0008171) Curated
PM
AN	O-methyltransferases : the family includes also bacterial O-methyltransferases that may be involved in antibiotic production.
CC	COG: [R] General function prediction only;
CC	MODEL: XFF4834R
CC	STATUS: curated by darrasse (20120402)
MW	21357 Da
SQ	199 aa
	........10........20........30........40........50 \| \| \| \| \| MRTLQDLKGQLSRFGADNDAVETARGKRMLNITPETGELLALLALLVHAT QARQVVEVGTSNGYSTLWLAEAVIAVGGHVITLEHAEDKAALAAANFVRA GLQAHITQVPGDAGAWLETADDASVDLLFLDADRSAYTRWWPQLRRVLKP GAGLIVVDNATSHATEMADFTQAVRADMSFRCSEVSVGNGQFMAVRVAD

Domain decomposition

NP_642438.1 lcl|mdmC-XAC2121

199

S=838 I=83 E=1.01165e-94

O-methyltransferase

Q9AQJ7 sp|Q9AQJ7|Q9AQJ7_9GAMM

195

S=238 I=38 E=1.49023e-20

O-methyl transferase

Pubmed 11160120

prodomImg

Q15JF1 sp|Q15JF1|Q15JF1_STRHY

177

S=184 I=36 E=5.983e-14

Putative O-methyltransferase

Pubmed 16725283

prodomImg

B2WW40 sp|B2WW40|B2WW40_9ACTO

159

S=171 I=38 E=1.97382e-12

O-methyltransferase

Pubmed 16707707

prodomImg

Q8KUG5 sp|Q8KUG5|Q8KUG5_ACTPA

169

S=168 I=42 E=4.55839e-12

O-methyltransferase

Pubmed 12060743

prodomImg

Q00719 sp|Q00719|MDMC_STRMY

159

S=167 I=33 E=7.29933e-12

O-methyltransferase mdmC EC=2.1.1.- ; Antibiotic biosynthesis Metal-binding S-adenosyl-L-methionine

Pubmed 1629172

prodomImg

C0SMX1 sp|C0SMX1|C0SMX1_9ACTO

159

S=158 I=35 E=7.68492e-11

O-methyl transferase

Pubmed 16707708,18708355

prodomImg

Q3S882 sp|Q3S882|Q3S882_9ACTO

159

S=152 I=38 E=4.55079e-10

Methoxymalonate biosynthesis protein

Pubmed 16207901

prodomImg

Q50859 sp|Q50859|Q50859_MYXXA

159

S=149 I=35 E=1.0328e-09

Putative O-methyltransferase

Pubmed 7551044,8936303

prodomImg

Q15BR1 sp|Q15BR1|Q15BR1_OXYMA

160

S=142 I=36 E=7.34483e-09

3-dehydroquinate synthase/O-methyltransferase fusion

Pubmed 16675503

prodomImg

Q9KIE7 sp|Q9KIE7|Q9KIE7_STRHY

159

S=142 I=35 E=7.40915e-09

FkbG

Pubmed 10863099

prodomImg

Q00719 sp|Q00719|MDMC_STRMY

159

S=167 I=33 E=5.05926e-12

O-methyltransferase mdmC EC=2.1.1.- ; Antibiotic biosynthesis Metal-binding S-adenosyl-L-methionine

prodomImg

[G3DSA:3.40.50.150]

164

IPR002935 [PF01596]

197

O-methyltransferase, family 3

[seg]

PD002981

180

S=188 I=30 E=2.63895e-15

PD245993

109

159

S=117 I=53 E=1.06698e-06

Suggestions

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Move your mouse over each field to get more informations
ID
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Access unfiltered results

	Set of Uniprot with relevant PubMed cross-references ncbi-blastp	18 hits
	Swiss-Prot ncbi-blastp	1 hits
	Xanthomonas fuscans subsp. fuscans proteome ncbi-blastp	0 hits
	HAMAP scan	0 hits
	IprScan	4 hits

Miscellaneous analyses

ERROR Tag PERLLIB Portal/Tools.pl GetLocalBlastButton\("/www/bacteria/annotation//site//www/bacteria/annotation//site/tmp/WB7w4KCm/XFF4834R_chr22210.xml_fasta", "https://iant.toulouse.inra.fr/bacteria/annotation/web/img/XFF4834R.png"\) - ERROR: No such file or directory at /www/bacteria/annotation/cgi/XFF4834R/../../lib/iANT/Entry/Display.pm line 164.

ERROR Tag PERLLIB Portal/Tools.pl GetNcbiBlastButton\("/www/bacteria/annotation//site//www/bacteria/annotation//site/tmp/WB7w4KCm/XFF4834R_chr22210.xml_fasta", "blastp"\) - ERROR: No such file or directory at /www/bacteria/annotation/cgi/XFF4834R/../../lib/iANT/Entry/Display.pm line 164.

ERROR Tag PERLLIB Portal/Tools.pl GetUniprotBlastButton\("/www/bacteria/annotation//site//www/bacteria/annotation//site/tmp/WB7w4KCm/XFF4834R_chr22210.xml_fasta"\) - ERROR: No such file or directory at /www/bacteria/annotation/cgi/XFF4834R/../../lib/iANT/Entry/Display.pm line 164.

ERROR Tag PERLLIB Portal/Tools.pl GetKeggBlastButton\("/www/bacteria/annotation//site//www/bacteria/annotation//site/tmp/WB7w4KCm/XFF4834R_chr22210.xml_fasta", "blastp"\) - ERROR: No such file or directory at /www/bacteria/annotation/cgi/XFF4834R/../../lib/iANT/Entry/Display.pm line 164.

XFF4834R_chr_3005234_3005890_f2_XFF4834R-XFF4834R_chr26010 XFF4834R_chr26010

ID	XFF4834R_chr_3005234_3005890_f2_XFF4834R-XFF4834R_chr26010
AC	XFF4834R_chr26010
LT	XFF4834R_chr26010
OR	XFF4834R_chr from 3005234 to 3005890 on strand +
DE	putative HNH nuclease
IP	HNH nuclease
CL	5.10 Defense/survival GO:0006952
EC
GO	InterPro Molecular Function: endonuclease activity (GO:0004519) Molecular Function: nucleic acid binding (GO:0003676) Curated
PM
AN
CC	COG: [V] Defense mechanisms;
CC	MODEL: XFF4834R
CC	STATUS: curated by poussier (20100629)
MW	24230.5 Da
SQ	218 aa
	........10........20........30........40........50 \| \| \| \| \| METDTHVRDVIVPGGSYAPDAGSAVAAIHQLPTLRLLSLDAHGRVLDWIN WQDAACLYARDAVSWTLGEPCMQIHGGISRLTGERSALELHPIIAARGHA RSRALDPTPTLSNTALFARDSQLCMYCGQHFSRPHLTRDHVMPVSKGGRD SWENVVTACFQCNSRKANRTPQQAHMPLLAVPYRPSWIEHLILSNRNILS DQMAFLRAQLPKRSKLSL

NP_642878.2 lcl|XAC2564-XAC2564

218

S=1152 I=99 E=1.09926e-132

hypothetical protein

YP_364494.1 lcl|XCV2763

218

S=1143 I=99 E=1.10796e-131

HNH endonuclease family protein

NP_637786.2 lcl|XCC2433

218

S=1090 I=94 E=3.48471e-125

hypothetical protein

lcl|XALc_1083

217

S=923 I=79 E=4.85706e-105

hypothetical protein

Q306Z6 sp|Q306Z6|Q306Z6_SPIPL

110

178

S=202 I=54 E=5.49142e-16

HNH endonuclease

Pubmed 16368872

prodomImg

Q306Z7 sp|Q306Z7|Q306Z7_SPIPL

111

185

S=184 I=47 E=8.40423e-14

HNH endonuclease

Pubmed 16368872

prodomImg

Q8SDH4 sp|Q8SDH4|Q8SDH4_BPLLH

116

170

S=115 I=35 E=1.48425e-05

Putative uncharacterized protein

Pubmed 7514146,8917075

prodomImg

A4ZRD2 sp|A4ZRD2|A4ZRD2_9CAUD

116

173

S=110 I=45 E=7.38283e-05

HNH endonuclease

Pubmed 17383677

prodomImg

Q8W6W4 sp|Q8W6W4|Q8W6W4_9CAUD

116

168

S=109 I=46 E=8.48803e-05

Putative uncharacterized protein

Pubmed 11976141

prodomImg

IPR002711 [PF01844]

122

169

HNH endonuclease

IPR003615 [SM00507]

111

164

HNH nuclease

PD284088

134

S=331 I=61 E=1.35919e-32

PD860184

168

216

S=184 I=69 E=7.73039e-15

PDA2I8A5

S=159 I=89 E=7.38211e-12

PDA5R9F5

103

194

S=126 I=36 E=9.06998e-08

PD644509

S=122 I=92 E=2.76872e-07

PD077169

136

166

S=101 I=59 E=8.81371e-05

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ID
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Access unfiltered results

	Set of Uniprot with relevant PubMed cross-references ncbi-blastp	6 hits
	Swiss-Prot ncbi-blastp	0 hits
	Xanthomonas fuscans subsp. fuscans proteome ncbi-blastp	0 hits
	HAMAP scan	0 hits
	IprScan	2 hits

Miscellaneous analyses

ERROR Tag PERLLIB Portal/Tools.pl GetLocalBlastButton\("/www/bacteria/annotation//site//www/bacteria/annotation//site/tmp/WB7w4KCm/XFF4834R_chr26010.xml_fasta", "https://iant.toulouse.inra.fr/bacteria/annotation/web/img/XFF4834R.png"\) - ERROR: No such file or directory at /www/bacteria/annotation/cgi/XFF4834R/../../lib/iANT/Entry/Display.pm line 164.

ERROR Tag PERLLIB Portal/Tools.pl GetNcbiBlastButton\("/www/bacteria/annotation//site//www/bacteria/annotation//site/tmp/WB7w4KCm/XFF4834R_chr26010.xml_fasta", "blastp"\) - ERROR: No such file or directory at /www/bacteria/annotation/cgi/XFF4834R/../../lib/iANT/Entry/Display.pm line 164.

ERROR Tag PERLLIB Portal/Tools.pl GetUniprotBlastButton\("/www/bacteria/annotation//site//www/bacteria/annotation//site/tmp/WB7w4KCm/XFF4834R_chr26010.xml_fasta"\) - ERROR: No such file or directory at /www/bacteria/annotation/cgi/XFF4834R/../../lib/iANT/Entry/Display.pm line 164.

ERROR Tag PERLLIB Portal/Tools.pl GetKeggBlastButton\("/www/bacteria/annotation//site//www/bacteria/annotation//site/tmp/WB7w4KCm/XFF4834R_chr26010.xml_fasta", "blastp"\) - ERROR: No such file or directory at /www/bacteria/annotation/cgi/XFF4834R/../../lib/iANT/Entry/Display.pm line 164.

XFF4834R_chr_4927858_4928139_f1_XFF4834R-XFF4834R_chr42450 XFF4834R_chr42450

ID	XFF4834R_chr_4927858_4928139_f1_XFF4834R-XFF4834R_chr42450
AC	XFF4834R_chr42450
LT	XFF4834R_chr42450
OR	XFF4834R_chr from 4927858 to 4928139 on strand +
DE	putative toxin of the YafQ-DinJ toxin-antitoxin system
IP	Plasmid stabilization system; Addiction module toxin, RelE/StbE
CL	5.10 Defense/survival GO:0006952
EC
GO	InterPro Curated
PM
AN
CC	COG: [S] Function unknown;
CC	MODEL: XFF4834R
CC	STATUS: curated by jacques (20100916)
MW	10678.9 Da
SQ	93 aa
	........10........20........30........40........50 \| \| \| \| \| MRTIDRSSAFKRDYKREAKGQHRATLDDAIKPVLVALATDQPPDARYRDH DLSGDWAGYRECHIKPDLLLIYRKSDPDTLRLARLGSHSELFG

Q6UPA5 sp|Q6UPA5|Q6UPA5_RALEJ

S=339 I=71 E=2.12995e-33

Plasmid stabilization system Putative uncharacterized protein

Pubmed 15186344

prodomImg

Q7X3B4 sp|Q7X3B4|Q7X3B4_9BACT

S=339 I=71 E=2.12995e-33

Hypothetical Xf2080 protein ; Plasmid

Pubmed 14600226

prodomImg

A7K7H5 sp|A7K7H5|A7K7H5_9BURK

S=339 I=71 E=2.12995e-33

Putative uncharacterized protein ; Plasmid

Pubmed 15580337,16517619

prodomImg

B0YN41 sp|B0YN41|B0YN41_9NEIS

S=324 I=90 E=1.66579e-31

Putative addiction module toxin ; Plasmid

Pubmed 18227089

prodomImg

A1Y2V8 sp|A1Y2V8|A1Y2V8_9BACT

S=322 I=90 E=2.32011e-31

Putative uncharacterized protein ; Plasmid

Pubmed 17261525

prodomImg

Q68E62 sp|Q68E62|Q68E62_AERPU

S=317 I=89 E=1.00379e-30

Putative uncharacterized protein

Pubmed 15574953

prodomImg

A0AED9 sp|A0AED9|A0AED9_9BACT

S=317 I=89 E=1.00379e-30

Putative uncharacterized protein ; Plasmid

Pubmed 17101677

prodomImg

Q8KKE2 sp|Q8KKE2|Q8KKE2_HELPY

S=182 I=43 E=2.24786e-14

Putative uncharacterized protein orf4H ; Plasmid

Pubmed 11976306

prodomImg

Q8KKD2 sp|Q8KKD2|Q8KKD2_HELPY

S=182 I=43 E=2.36858e-14

Putative uncharacterized protein orf5F ; Plasmid

Pubmed 11976306

prodomImg

Q3LR61 sp|Q3LR61|Q3LR61_HELPY

S=179 I=42 E=6.18022e-14

R3 ; Plasmid

Pubmed 7806390,17921278

prodomImg

Q47149 sp|Q47149|YAFQ_ECOLI

S=154 I=38 E=3.56366e-11

Uncharacterized protein yafQ

prodomImg

P44041 sp|P44041|Y711_HAEIN

S=136 I=34 E=5.31313e-09

Uncharacterized protein HI0711

prodomImg

IPR007712 [PF05016]

Plasmid stabilisation system

IPR012753 [TIGR02385]

Addiction module toxin, RelE/StbE

PDA6M5N9

S=152 I=66 E=5.53836e-11

PD423708

S=128 I=74 E=4.84725e-08

Suggestions

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ID
DE
EC
GO
PM
CC
CL
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	Validation code (copy this one AUcd9WvQ)

Access unfiltered results

	Set of Uniprot with relevant PubMed cross-references ncbi-blastp	16 hits
	Swiss-Prot ncbi-blastp	2 hits
	Xanthomonas fuscans subsp. fuscans proteome ncbi-blastp	0 hits
	HAMAP scan	0 hits
	IprScan	2 hits

Miscellaneous analyses

ERROR Tag PERLLIB Portal/Tools.pl GetLocalBlastButton\("/www/bacteria/annotation//site//www/bacteria/annotation//site/tmp/WB7w4KCm/XFF4834R_chr42450.xml_fasta", "https://iant.toulouse.inra.fr/bacteria/annotation/web/img/XFF4834R.png"\) - ERROR: No such file or directory at /www/bacteria/annotation/cgi/XFF4834R/../../lib/iANT/Entry/Display.pm line 164.

ERROR Tag PERLLIB Portal/Tools.pl GetNcbiBlastButton\("/www/bacteria/annotation//site//www/bacteria/annotation//site/tmp/WB7w4KCm/XFF4834R_chr42450.xml_fasta", "blastp"\) - ERROR: No such file or directory at /www/bacteria/annotation/cgi/XFF4834R/../../lib/iANT/Entry/Display.pm line 164.

ERROR Tag PERLLIB Portal/Tools.pl GetUniprotBlastButton\("/www/bacteria/annotation//site//www/bacteria/annotation//site/tmp/WB7w4KCm/XFF4834R_chr42450.xml_fasta"\) - ERROR: No such file or directory at /www/bacteria/annotation/cgi/XFF4834R/../../lib/iANT/Entry/Display.pm line 164.

ERROR Tag PERLLIB Portal/Tools.pl GetKeggBlastButton\("/www/bacteria/annotation//site//www/bacteria/annotation//site/tmp/WB7w4KCm/XFF4834R_chr42450.xml_fasta", "blastp"\) - ERROR: No such file or directory at /www/bacteria/annotation/cgi/XFF4834R/../../lib/iANT/Entry/Display.pm line 164.

tldD XFF4834R_chr18650

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tldE XFF4834R_chr18670

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XFF4834R_chr24170719_2568318_f1_XFF4834R-XFF4834R_chr22210 XFF4834R_chr22210

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XFF4834R_chr_3005234_3005890_f2_XFF4834R-XFF4834R_chr26010 XFF4834R_chr26010

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XFF4834R_chr_4927858_4928139_f1_XFF4834R-XFF4834R_chr42450 XFF4834R_chr42450

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